CRISPR/Cas12a cleavage-mediated isothermal amplification lights up the dimeric G-quadruplex signal unit for ultrasensitive and label-free detection of circulating tumor DNA
Jiangbo Dong, Xinyao Li, Liyuan Deng, Shiying Zhou, Jingzhou Hou, Changjun Hou, Danqun Huo
Topics & Concepts
CRISPRDNAFluorescenceG-quadruplexAptamerChemistryBiosensorPrimer (cosmetics)Computational biologyMolecular biologyOligonucleotideCombinatorial chemistryBiophysicsBiologyBiochemistryGeneQuantum mechanicsPhysicsOrganic chemistryAdvanced biosensing and bioanalysis techniquesCRISPR and Genetic EngineeringDNA and Nucleic Acid Chemistry