Halogen-Substituted Allenyl Ketones through Ring Opening of Nonstrained Cycloalkanols
Penglin Wu, Shengming Ma
Abstract
An efficient synthesis of halogen-substituted allenyl ketones via Ag-catalyzed oxidative ring opening of allenyl cyclic alcohols under mild reaction conditions has been achieved. The reaction features a wide substrate scope and excellent regioselectivity. The synthetic potential of the products has been demonstrated by their conversion to stereodefined alkenes and heterocyclic compounds.
Topics & Concepts
ChemistryRegioselectivityHalogenRing (chemistry)Substrate (aquarium)CatalysisCombinatorial chemistryScope (computer science)Oxidative phosphorylationOrganic chemistryMedicinal chemistryBiochemistryOceanographyComputer scienceProgramming languageAlkylGeologyCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsSulfur-Based Synthesis Techniques