Metal-free domino amination-Knoevenagel condensation approach to access new coumarins as potent nanomolar inhibitors of VEGFR-2 and EGFR
Essam M. Eliwa, Marcel Frese, Ahmed H. Halawa, Maha M. Soltan, Larissa V. Ponomareva, Jon S. Thorson, Khaled A. Shaaban, Mohamed Shaaban, Ahmed M. El‐Agrody, Norbert Sewald
Abstract
values of 24.67 nM and 31.6 nM that were almost equipotent to sorafenib (31.08 nM) and erlotinib (26.79 nM), respectively.
Topics & Concepts
ChemistryKnoevenagel condensationCoumarinIC50PotencyDocking (animal)CytotoxicityReductive aminationAminationStereochemistryCombinatorial chemistryIn vitroBiochemistryOrganic chemistryNursingMedicineCatalysisLung Cancer Treatments and MutationsCancer therapeutics and mechanismsSynthesis and biological activity