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Design and synthesis of novel substituted benzyl pyrrolopyrimidine derivatives as selective BTK inhibitors for treating mantle cell lymphoma

Fansheng Ran, Yang Liu, Xin Chen, Huijun Zhuo, Changqing Xu, Yuxia Li, Xiaoming Duan, Guisen Zhao

2021Bioorganic Chemistry11 citationsDOI

Topics & Concepts

IbrutinibBruton's tyrosine kinaseChemistryMantle cell lymphomaTyrosine kinasePharmacologyKinaseCancer researchLymphomaSignal transductionBiochemistryLeukemiaInternal medicineChronic lymphocytic leukemiaMedicineChronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and TreatmentViral-associated cancers and disorders
Design and synthesis of novel substituted benzyl pyrrolopyrimidine derivatives as selective BTK inhibitors for treating mantle cell lymphoma | Litcius