GATA1 deletion in human pluripotent stem cells increases differentiation yield and maturity of neutrophils
Thomas C. Harper, Elaine M. Oberlick, Tomas J. Smith, Duncan E. Nunes, Mark‐Anthony Bray, Seonmi Park, Corey D. Driscoll, Sarah F. Mowbray, Christophe Antczak
Abstract
KO iNeutrophils are a powerful tool in determining involvement of a given protein in NET formation.
Topics & Concepts
Induced pluripotent stem cellGATA1Neutrophil extracellular trapsCell biologyBiologyPhenotypeCellular differentiationStem cellImmunologyEmbryonic stem cellHaematopoiesisGeneticsInflammationGeneNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancerBlood disorders and treatments