Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis
Caiwei Yu, Hui Liu, Chunjing Guo, Qiang Chen, Yanguo Su, Huimin Guo, Xiaoya Hou, Feng Zhao, Huaying Fan, Hui Xu, Yan Zhao, Xiaofeng Mu, Guohua Wang, Haiyu Xu, Daquan Chen
Abstract
experiments showed that DPC@Cel have better anti-rheumatoid arthritis effects and lower systemic toxicity than free Cel. This study provided a new therapeutic strategy for the treatment of RA.
Topics & Concepts
Rheumatoid arthritisPharmacologyDextranScavenger receptorMicelleIn vivoMatrix metalloproteinaseArthritisDrug deliveryBioavailabilityChemistryMedicineMaterials scienceImmunologyBiochemistryBiologyAqueous solutionLipoproteinCholesterolBiotechnologyPhysical chemistryOrganic chemistryNatural Compounds in Disease TreatmentRheumatoid Arthritis Research and TherapiesImmunotherapy and Immune Responses