Whey protein and soy protein prevent obesity by upregulating uncoupling protein 1 to activate brown adipose tissue and promote white adipose tissue browning in high-fat diet-fed mice
Andong Ji, Wei Chen, Tianyu Zhang, Runjia Shi, Xinqi Wang, Yan Wang, Huina Xu, Duo Li
Abstract
in BAT, iWAT and eWAT in the 10% WPI group were significantly lower compared with the 10% SPI group. In conclusion, whey protein was more effective than soy protein in preventing obesity in mice, probably by suppressing lipogenesis in adipose tissues, activating BAT and promoting the browning of iWAT. In addition, lowering the P/C ratio was beneficial for combating obesity in the context of a HFD.
Topics & Concepts
White adipose tissueAdipose tissueBrowningBrown adipose tissueSoy proteinPRDM16Uncoupling proteinThermogeninObesityEndocrinologyInternal medicineFood scienceChemistryBiologyMedicineAdipose Tissue and MetabolismMuscle metabolism and nutritionDiet and metabolism studies