Concurrent Cu(<scp>ii</scp>)-initiated Fenton-like reaction and glutathione depletion to escalate chemodynamic therapy
Ashwini Kumar, Ayushi Chaudhary, Bhumika Agrahari, Kajal Chaudhary, Pooran Kumar, Ritika Gautam Singh
Abstract
= 5.3 μM, MCF-7) complex exclusively depletes glutathione while simultaneously promoting ROS production. Cu(L2)2 also affects other macromolecules like the mitochondrial membrane and DNA while activating the unfolded protein response cascade.
Topics & Concepts
ChemistryGlutathioneBiophysicsMacromoleculeBiochemistryReactive oxygen speciesCell biologyCombinatorial chemistryBiologyEnzymeMetal complexes synthesis and propertiesClick Chemistry and ApplicationsNanoparticle-Based Drug Delivery