Cyclometalated Ru(II) β-carboline complexes induce cell cycle arrest and apoptosis in human HeLa cervical cancer cells via suppressing ERK and Akt signaling
Jincan Chen, Yuanyuan Deng, Jie Wang, Suxiang Chen, Fa Peng, Xuerong He, Meijun Liu, Hui Luo, Jingjing Zhang, Lanmei Chen
Topics & Concepts
HeLaChemistryApoptosisProtein kinase BMAPK/ERK pathwayReactive oxygen speciesCell cycle checkpointCancer cellCell growthPoly ADP ribose polymeraseCell cycleCytochrome cMolecular biologySignal transductionCellBiochemistryBiologyCancerPolymeraseDNAGeneticsSynthesis and bioactivity of alkaloidsMetal complexes synthesis and propertiesCancer Mechanisms and Therapy