Heterogeneous Fe single-atom catalysis for C2–H amidation of pyridine/quinoline <i>N</i>-oxides: streamlined synthesis of pharmaceutical scaffolds
Jinhua Ou, Song Yu, Duoduo Liu, Han Jiang, Can Lyu, Keyi Chen, Jie Li, Zhuobin Yu, Kaijian Liu, Jinxuan Liu
Abstract
This first heterogeneous catalytic system enables base/additive-free C2–H amidation of N -oxides with 100% atom economy for pharmaceutical synthesis.
Topics & Concepts
QuinolineChemistryCatalysisPyridineCombinatorial chemistryAtom (system on chip)Organic chemistryMedicinal chemistryComputer scienceEmbedded systemCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsSynthesis and Biological Evaluation