Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction
Aaron Troy, Diyora Normukhamedova, Daniela Grothe, Abdul Momen, Yuqing Zhou, Meghan J. McFadden, Mansoor Husain, Filio Billia, Hai‐Ling Margaret Cheng
Abstract
This is the first preclinical study to examine the impact of ovary-intact menopause [accelerated ovarian failure (AOF)] on HFpEF. Echocardiography of young female mice revealed early evidence of diastolic and systolic cardiac dysfunction apparent only on strain imaging in HFpEF only, AOF only, or the combination. Surprisingly, AOF did not exacerbate the HFpEF phenotype. Results in middle-aged "old" females also showed no interaction between HFpEF and AOF and, importantly, no cardiovascular impact from HFpEF or AOF.
Topics & Concepts
Internal medicineHeart failure with preserved ejection fractionMedicineHeart failureMenopauseDiastoleCardiologyContext (archaeology)EndocrinologyEjection fractionBlood pressurePressure overloadBiologyPaleontologyCardiac hypertrophyHormonal Regulation and HypertensionNitric Oxide and Endothelin EffectsCardiovascular Function and Risk Factors