Litcius/Paper detail

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer

Kevin Lin, Justine C. Rutter, Abigail Xie, Bryann Pardieu, Emily T. Winn, Reinaldo Dal Bello, Antoine Forget, Raphaël Itzykson, Lucie Ahn, Ziwei Dai, Raiyan T. Sobhan, Grace R. Anderson, Katherine R. Singleton, Amy E. Decker, Peter Winter, Jason W. Locasale, Lorin Crawford, Alexandre Puissant, Kris C. Wood

2020Nature Genetics90 citationsDOI

Topics & Concepts

BiologyPleiotropyDrug resistanceGeneticsCRISPRBromodomainComputational biologyEpigeneticsGenePhenotypeProtein Degradation and InhibitorsEvolution and Genetic DynamicsCRISPR and Genetic Engineering