Synthesis and biological evaluation of novel 2,4-dianilinopyrimidine derivatives as potent dual janus kinase 2 and histone deacetylases inhibitors
Haiping Zhou, Junhao Jiang, Jinyu Lu, Dongzhi Ran, Zongjie Gan
Topics & Concepts
ChemistryAcetylationHistoneKinaseHDAC1Janus kinaseHistone H3ApoptosisCell cycleCell cycle checkpointCancer researchCell biologyHistone deacetylaseBiochemistryDNABiologyGeneHistone Deacetylase Inhibitors ResearchPhytochemical compounds biological activitiesCancer Mechanisms and Therapy