Gambogic acid suppresses the pentose phosphate pathway by covalently inhibiting 6PGD protein in cancer cells
Yinhua Zhu, Ying Zhang, Qianyu Zhang, Ang Ma, Ying Zhang, Chen Wang, Peng Gao, Qiuyan Guo, Fei Xia, Huan Tang, Chengchao Xu, Jigang Wang
Abstract
regulating the cellular metabolic process remains unclear. Here we report that gambogic acid suppresses the pentose phosphate pathway (PPP) by covalently inhibiting the 6-phosphogluconate dehydrogenase (6PGD) protein. This study elucidates the mechanism of action of gambogic acid from the perspective of metabolic reprogramming regulation in cancer cells.
Topics & Concepts
Gambogic acidPentose phosphate pathwayChemistryBiochemistryPhosphateCovalent bondCancerEnzymeBiologyGlycolysisOrganic chemistryIn vitroGeneticsNatural Compound Pharmacology StudiesCancer, Hypoxia, and MetabolismCarbohydrate Chemistry and Synthesis