Regulatory T cells engineered with TCR signaling–responsive IL-2 nanogels suppress alloimmunity in sites of antigen encounter
Siawosh K. Eskandari, Ina Sulkaj, Mariane B. Melo, Na Li, Hazim Allos, Juliano Alhaddad, Branislav Kollár, Thiago J. Borges, Arach S. Eskandari, Max Zinter, Songjie Cai, Jean Pierre Assaker, John Y. Choi, Basmah S. Al Dulaijan, Amr Mansouri, Yousef Haik, Bakhos A. Tannous, Willem J. van Son, Henri G. D. Leuvenink, Bohdan Pomahač, Leonardo V. Riella, Li Tang, Marc A. Seelen, Darrell J. Irvine, Jamil Azzi
Abstract
Redox-sensitive cytokine cargoes backpacked on regulatory T cells promote local immune regulation in areas of rejection.
Topics & Concepts
AlloimmunityT-cell receptorCell biologyImmunologyAntigenChemistryT cellCancer researchBiologyImmune systemT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction