Melting point–solubility–structure correlations in chiral and racemic model cocrystals
Ornella E. Y. Kilinkissa, Krishna K. Govender, Nikoletta B. Báthori
Abstract
Comparison of chiral and racemic binary cocrystals showed that the chiral building block limits the formation of certain intermolecular interactions, decreases the packing efficiency, lowers the melting point and increases aqueous solubility.
Topics & Concepts
SolubilityMelting pointIntermolecular forceMaterials scienceAqueous solutionBinary numberChemistryThermodynamicsOrganic chemistryMoleculeMathematicsPhysicsArithmeticCrystallography and molecular interactionsCrystallization and Solubility StudiesSpectroscopy and Quantum Chemical Studies