Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance
Lai Wei, Xiangdong He, Deming Zhao, Martha Kandawa-Shultz, Guoqiang Shao, Yihong Wang
Topics & Concepts
ChemistrySinglet oxygenPhototoxicityPhotodynamic therapyReactive oxygen speciesA549 cellPhotochemistryPhotosensitizerApoptosisBiophysicsQuenching (fluorescence)DNA damageIntracellularRedoxFluorescenceDNAOxygenBiochemistryIn vitroQuantum mechanicsOrganic chemistryBiologyPhysicsNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAdvanced biosensing and bioanalysis techniques