Ginsenoside Rb1 Alleviated High‐Fat‐Diet‐Induced Hepatocytic Apoptosis via Peroxisome Proliferator‐Activated Receptor <i>γ</i>
Bing Song, Yao Sun, Yafen Chu, Jing Wang, Hongwei Zheng, Lili Liu, Wang Cai, Haoqiang Zhang
Abstract
Objective . High‐fat‐diet‐ (HFD‐) induced hepatic cell apoptosis is common in mice with nonalcoholic fatty liver disease (NAFLD). We aim to investigate the effect of Ginsenoside Rb1 (GRb1) on hepatocyte apoptosis. Methods . C57BL/6J mice with HFD were used to induce a liver‐injured model with cell apoptosis. In addition, GRb1 was used to treat HFD‐induced apoptosis in a liver with or without inhibitor of peroxisome proliferator‐activated receptor γ (PPAR‐ γ ). Results . Compared with C57BL/6J mice with common chow, there are downregulated PPAR‐ γ but upregulated cell apoptosis in the liver of mice with HFD. Furthermore, GRb1 elevated the hepatic PPAR‐ γ level and suppressed hepatocytic apoptosis. However, GW9662 abolished the effects of GRb1 on apoptosis in the liver. Conclusions . GRb1 alleviated HFD‐induced apoptosis of hepatocytes of mice via PPAR‐ γ .