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PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis

Hai‐Liang Zhang, Bingxin Hu, Zhi‐Ling Li, Tian Du, Jia‐Lu Shan, Zhipeng Ye, Xiao-Dan Peng, Xuan Li, Yun Huang, Xianying Zhu, Yuhong Chen, Gong‐Kan Feng, Dajun Yang, Rong Deng, Xiao‐Feng Zhu, Xiao‐Feng Zhu, Xiao‐Feng Zhu

2022Nature Cell Biology548 citationsDOI

Topics & Concepts

Lipid peroxidationLipidomicsCell biologyBiochemistryGPX4ChemistryPhosphorylationLipid signalingProtein kinase CBiologyAntioxidantEnzymeSuperoxide dismutaseGlutathione peroxidaseFerroptosis and cancer prognosisRNA modifications and cancerCancer-related molecular mechanisms research
PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis | Litcius