Multicountry Spread of Influenza A(H1N1)pdm09 Viruses with Reduced Oseltamivir Inhibition, May 2023–February 2024
Mira C. Patel, Ha Nguyen, Philippe Noriel Q. Pascua, Rongyuan Gao, John Steel, Rebecca Kondor, Larisa V. Gubareva
Abstract
Since May 2023, a novel combination of neuraminidase mutations, I223V + S247N, has been detected in influenza A(H1N1)pdm09 viruses collected in countries spanning 5 continents, mostly in Europe (67/101). The viruses belong to 2 phylogenetically distinct groups and display ≈13-fold reduced inhibition by oseltamivir while retaining normal susceptibility to other antiviral drugs.
Topics & Concepts
OseltamivirVirologyInfluenza A virusMedicineCoronavirus disease 2019 (COVID-19)Internal medicineVirusInfectious disease (medical specialty)DiseaseInfluenza Virus Research StudiesProtein Structure and DynamicsCOVID-19 epidemiological studies