The Potent PDE10A Inhibitor MP-10 (PF-2545920) Suppresses Microglial Activation in LPS-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models
Do‐Yeon Kim, Jin‐Sun Park, Yea-Hyun Leem, Jung-Eun Park, Hee-Sun Kim
Topics & Concepts
NeuroinflammationProinflammatory cytokineMPTPSubstantia nigraNitric oxide synthaseChemistryTumor necrosis factor alphaMicrogliaProtein kinase BPharmacologyEndocrinologyMolecular biologyNitric oxideInternal medicineBiologySignal transductionImmunologyDopaminergicDopamineBiochemistryInflammationMedicineNeuroinflammation and Neurodegeneration MechanismsPhosphodiesterase function and regulationAdenosine and Purinergic Signaling