Metabolic Imaging Patterns on 18F-FDG PET in Acute and Subacute LGI1 Autoimmune Limbic Encephalitis
Nikhil Seniaray, Ritu Verma, Rajeev Ranjan, Ethel Belho, Harsh Mahajan
Abstract
Autoimmune encephalitis is a diverse group of neuropsychiatric disorders, which are difficult to diagnose clinically. The disorder presents acutely or subacutely with alteration of consciousness, cognitive decline, seizures, and abnormal movements. Autoantibodies are directed against intracellular antigens or extracellular domains of cell surface proteins, critical for neuronal excitability. F-FDG PET/CT has been used to diagnose the metabolic derangement in the brain due to various antibodies. Here we describe a case where acute and subacute phase of disease was visualized on serial F-FDG PET/CT.
Topics & Concepts
MedicineLimbic encephalitisAutoantibodyAutoimmune encephalitisPathologyNeuroscienceEncephalitisPositron emission tomographyExtracellularImmunologyAntibodyPsychologyBiologyVirusRadiologyCell biologyAutoimmune Neurological Disorders and TreatmentsPeripheral Neuropathies and DisordersCellular transport and secretion