Cardiotoxicity Hazard and Risk Characterization of ToxCast Chemicals Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes from Multiple Donors
Sarah D. Burnett, Alexander D. Blanchette, Weihsueh A. Chiu, Ivan Rusyn
Abstract
model for rapid, high-throughput hazard and risk characterization of chemicals for which little to no cardiotoxicity data are available from guideline studies in animals.
Topics & Concepts
CardiotoxicityInduced pluripotent stem cellStem cellCellHazardMedicinePharmacologyChemistryBiologyCell biologyInternal medicineToxicityBiochemistryEmbryonic stem cellGeneOrganic chemistryPluripotent Stem Cells Research3D Printing in Biomedical ResearchAnimal testing and alternatives