Adaptation of A-to-I RNA editing in bacteria, fungi, and animals
Yuange Duan, Hu Li, Wanzhi Cai
Abstract
A-to-I RNA editing is prevalent in all domains of lives Adenosine-to-inosine (A-to-I) RNA editing is a prevalent type of RNA modification in all domains of lives ranging from bacteria (Liao et al., 2023), fungi (Liu et al., 2017), to metazoans (Duan et al., 2018;Zhang et al., 2023).Inosine is believed to be recognized as guanosine (G) (Figure 1A) and therefore A-to-I RNA editing is able to change genetic information at RNA level.In coding sequence (CDS), non-synonymous editing sites will cause recoding events that largely diversify the proteome (Eisenberg and Levanon, 2018) (Figure 1B).The adaptation of A-to-I RNA editing in bacteria, fungi, and animals has been systematically summarized by a recent paper (Liao et al., 2023).In this article, we will follow this topic and make an in-depth but concise discussion on the evolutionary significance, biological consequence, and adaptive signals of A-to-I RNA editing.