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Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro

Hossein Mousavi, Behzad Zeynizadeh, Mehdi Rimaz

2023Bioorganic Chemistry38 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryAllosteric regulationComponent (thermodynamics)Combinatorial chemistryStereochemistryDrug discoveryDrugActive siteBiochemistryComputational biologyEnzymePharmacologyBiologyMedicineThermodynamicsPhysicsMulticomponent Synthesis of HeterocyclesSynthesis and biological activityComputational Drug Discovery Methods
Green and efficient one-pot three-component synthesis of novel drug-like furo[2,3-d]pyrimidines as potential active site inhibitors and putative allosteric hotspots modulators of both SARS-CoV-2 MPro and PLPro | Litcius