Targeting microtubule sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
Tan‐Min Chin, Gandhi T. K. Boopathy, Ellen P.S. Man, John G. Clohessy, Eva Csizmadia, Margaret P. Quinlan, Thomas Choudary Putti, Seow‐Ching Wan, Chen Xie, Azhar Ali, Fhu Chee Wai, Yan Shan Ong, Boon-Cher Goh, Jeff Settleman, Wanjin Hong, Elena Levantini, Daniel G. Tenen
Abstract
: We find that the combination of microtubule stabilizing agent and lysosome inhibitor could reduce the tumor progression in EGFR TKI resistant mouse models of lung cancer.
Topics & Concepts
DrugMicrotubuleLung cancerCancer researchCancerPharmacologyChemistryAnticancer drugMedicineBiologyCell biologyPathologyInternal medicineChronic Lymphocytic Leukemia ResearchCancer-related Molecular PathwaysMicrotubule and mitosis dynamics