Transition-metal-free hydroamination/defluorination/cyclization of perfluoroalkyl alkynes with amidines
Li-Wen Sun, Zi-Lun Yu, Xin-Long Luo, Mengtao Ma, Zhi‐Liang Shen, Xue‐Qiang Chu
Abstract
An efficient defluorinative cyclization strategy for the construction of perfluoroalkyl-substituted pyrimidines by using perfluoroalkyl alkynes and amidines as substrates was developed.
Topics & Concepts
ChemistryHydroaminationTransition metalOrganic chemistryCombinatorial chemistryCatalysisFluorine in Organic ChemistryCyclopropane Reaction MechanismsCatalytic C–H Functionalization Methods