Structures of the σ2 receptor enable docking for bioactive ligand discovery
Assaf Alon, Jiankun Lyu, João M. Bráz, Tia A. Tummino, Veronica Craik, Matthew J. O’Meara, Chase M. Webb, Dmytro S. Radchenko, Yurii S. Moroz, Xi‐Ping Huang, Yongfeng Liu, Bryan L. Roth, John J. Irwin, Allan I. Basbaum, Brian K. Shoichet, Andrew C. Kruse
Topics & Concepts
AffinitiesDocking (animal)ReceptorVirtual screeningIn vivoChemistryBinding affinitiesDrug discoverySelectivityLigand (biochemistry)StereochemistryLigand efficiencyNeuropathic painPotencyPharmacologyIn vitroCombinatorial chemistryMedicineBiologyBiochemistryCatalysisNursingBiotechnologyPharmacological Receptor Mechanisms and EffectsNicotinic Acetylcholine Receptors StudyNeuropeptides and Animal Physiology