Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer
Tsai‐Tsen Liao, Chun‐Chi Lin, Jeng‐Kae Jiang, Shung-Haur Yang, Hao‐Wei Teng, Muh‐Hwa Yang
Abstract
: We reveal a noncanonical Notch pathway for activating Notch target genes, ISC genes, and PD-L1 in CRC. This finding explains the immune escape of CRCSCs and indicates a potential group that may benefit from immune checkpoint inhibitors. Epigenetic drugs for reversing stem-like features of CRC should also be investigated.
Topics & Concepts
Colorectal cancerCancer researchCancerBiologyChemistryCell biologyComputational biologyMedicineInternal medicineCancer Immunotherapy and BiomarkersCAR-T cell therapy researchCancer Cells and Metastasis