Neopterin Predicts Disease Severity in Hospitalized Patients With COVID-19
Rosa Bellmann‐Weiler, Lukas Lanser, Francesco Burkert, Stefanie Seiwald, Gernot Fritsche, Sophie Wildner, Andrea Schroll, Sabine Koppelstätter, Katharina Kurz, Andrea Griesmacher, Günter Weiß
Abstract
This study evaluates the predictive value of circulating inflammatory markers, especially neopterin, in patients with coronavirus disease 2019 (COVID-19). Within this retrospective analysis of 115 hospitalized COVID-19 patients, elevated neopterin levels upon admission were significantly associated with disease severity, risk for intensive care unit admission, need for mechanical ventilation, and death. Therefore, neopterin is a reliable predictive marker in patients with COVID-19 and may help to improve the clinical management of patients.
Topics & Concepts
NeopterinMedicineIntensive care unitCoronavirus disease 2019 (COVID-19)Mechanical ventilationDiseasePredictive valueInternal medicineSeverity of illnessRetrospective cohort studyIntensive care medicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronavirusPredictive value of testsInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Infectious Encephalopathies and Encephalitis