Rustrela Virus as Putative Cause of Nonsuppurative Meningoencephalitis in Lions
Madeleine de le Roi, Christina Puff, Peter Wohlsein, Florian Pfaff, Martin Beer, Wolfgang Baumgärtner, Dennis Rubbenstroth
Abstract
Retrospective investigation of archived tissue samples from 3 lions displaying nonsuppurative meningoencephalitis and vasculitis led to the detection of rustrela virus (RusV). We confirmed RusV antigen and RNA in cortical neurons, axons, astrocytes and Purkinje cells by reverse transcription quantitative PCR, immunohistochemistry, and in situ hybridization.
Topics & Concepts
MeningoencephalitisImmunohistochemistryIn situ hybridizationPathologyBiologyVirologyVirusReverse transcription polymerase chain reactionMedicineMessenger RNAGeneBiochemistryVirology and Viral DiseasesViral Infections and VectorsAnimal Virus Infections Studies