Discovery of Covalent MKK4/7 Dual Inhibitor
Jie Jiang, Baishan Jiang, Zhixiang He, Scott B. Ficarro, Jianwei Che, Jarrod A. Marto, Yang Gao, Tinghu Zhang, Nathanael S. Gray
Topics & Concepts
KinomeCovalent bondKinaseCysteineCancer researchChemistryPhosphorylationCell biologyBiochemistryBiologyEnzymeOrganic chemistryMelanoma and MAPK PathwaysCancer Mechanisms and TherapySynthesis and biological activity