Synthesis, in vivo anti-inflammatory, COX-1/COX-2 and 5-LOX inhibitory activities of new 2,3,4-trisubstituted thiophene derivatives
Nermeen A. Qandeel, Ashraf K. El‐Damasy, Maha H. Sharawy, Said M. Bayomi, Nadia S. El‐Gohary
Topics & Concepts
ChemistryCelecoxibIn vivoIC50PharmacologyArachidonate 5-lipoxygenaseIn vitroCarrageenanSelectivityThiopheneInhibitory postsynaptic potentialAnti-inflammatoryStereochemistryBiochemistryEnzymeArachidonic acidOrganic chemistryInternal medicineCatalysisMedicineBiologyBiotechnologyInflammatory mediators and NSAID effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents