Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration
Stephen Gadomski, Satyendra Kumar Singh, Shweta Singh, Tanmoy Sarkar, Kimberly D. Klarmann, Maximillian Berenschot, Steven Seaman, Brad L. Jakubison, Kristbjorn O. Gudmundsson, Stephen Lockett, Jonathan R. Keller
Abstract
mice do not survive sublethal irradiation because of impaired vessel regeneration and hematopoietic failure. Thus, Id genes are required for the survival and regeneration of BM SECs during homeostasis and stress to maintain HSC development.
Topics & Concepts
Regeneration (biology)HaematopoiesisSteady state (chemistry)Cell biologyBiologyCellHematopoietic cellChemistryStem cellBiochemistryPhysical chemistryHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchZebrafish Biomedical Research Applications