Exploring the Impact of Ionic Liquids on Pyrazole Derivatives Synthesis: A Critical Review
Shubham Sharma, Pooja Sharma, Bharti Budhalakoti, Akshay Kumar, Kuldeep Singh, Rupender Kumar Kamboj, Kanchna Bhatrola
Abstract
Abstract Researchers worldwide have increasingly focused on ionic liquids (ILs) in recent decades due to their distinctive properties and wide range of uses. Researchers are working on creating novel ILs and enhancing their characteristics to broaden their use across many industries. ILs are significant due to their versatility across various applications, and their utilization should take into account aspects such as cost, toxicity, and availability. Due to their unique properties, they have been extensively used as a green catalyst system in the synthesis of pyrazole derivatives. Pyrazole derivatives is privileged scaffolds among aza‐heterocycles owing to its various applications in drug discovery and materialistic program. A big task of green chemistry in organic synthesis has been fulfilled to the organic chemists towards the formation of valuable pyrazole‐based frameworks. This review explores the diverse applications of ILs in organic synthesis, specifically highlighting literature from 2004 to 2023 on the synthesis of pyrazole and its derivatives using IL‐assisted strategies. Specifically, it covers the synthesis of substituted pyrazoles, pyrazolo‐pyrans, quinolino‐triazolo‐triazepines, pyrazolo‐pyrimidines, and pyrazolo‐quinolinones. Also, reveals a role of IL as a catalyst and solvent on the synthesis of pyrazole derivatives.