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A GPX4 non-enzymatic domain and MDM2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction

F. Niu, Runyu Yang, Hui Feng, Yi Liu, Ruimin Liu, Bohan Ma

2023Biochemical and Biophysical Research Communications20 citationsDOI

Topics & Concepts

GPX4Cancer researchDrugProgrammed cell deathCancer cellCancerApoptosisMedicinePharmacologyBiologyEnzymeBiochemistryGlutathioneInternal medicineGlutathione peroxidasePeptidase Inhibition and AnalysisProtein Degradation and InhibitorsMultiple Myeloma Research and Treatments
A GPX4 non-enzymatic domain and MDM2 targeting peptide PROTAC for acute lymphoid leukemia therapy through ferroptosis induction | Litcius