Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in <i>Drosophila</i>
Masahiko Takemura, Fredrik Noborn, Jonas Nilsson, Nanako Bowden, Eriko Nakato, Sarah E. Baker, Tsu-Yi Su, Göran Larson, Hiroshi Nakato
Abstract
Using a recently developed glycoproteomic method, we identified a novel chondroitin sulfate proteoglycan, Windpipe (Wdp), in Drosophila. Wdp has three chondroitin sulfate sugar chains on the extracellular domain. We show that Wdp negatively regulates Hedgehog signaling via the chondroitin sulfate sugar chains.
Topics & Concepts
Chondroitin sulfateBiologyProteoglycanCell biologyHedgehogChondroitin sulfate proteoglycanChondroitinBiochemistryDecapentaplegicExtracellularMorphogenPerlecanExtracellular matrixSignal transductionGlycosaminoglycanDrosophila melanogasterGeneImaginal discProteoglycans and glycosaminoglycans researchWnt/β-catenin signaling in development and cancerHedgehog Signaling Pathway Studies