Enantioselective Total Synthesis of (−)‐Finerenone Using Asymmetric Transfer Hydrogenation
Andreas Lerchen, Narasimhulu Gandhamsetty, Elliot H. E. Farrar, Nils Winter, Johannes Platzek, Matthew N. Grayson, Varinder K. Aggarwal
Abstract
(-)-Finerenone is a nonsteroidal mineralocorticoid receptor antagonist currently in phase III clinical trials for the treatment of chronic kidney disease in type 2 diabetes. It contains an unusual dihydronaphthyridine core. We report a 6-step synthesis of (-)-finerenone, which features an enantioselective partial transfer hydrogenation of a naphthyridine using a chiral phosphoric acid catalyst with a Hantzsch ester. The process is complicated by the fact that the naphthyridine exists as a mixture of two atropisomers that react at different rates and with different selectivities. The intrinsic kinetic resolution was converted into a kinetic dynamic resolution at elevated temperature, which enabled us to obtain (-)-finerenone in both high yield and high enantioselectivity. DFT calculations have revealed the origin of selectivity.