Silk Fibroin Crosslinked Glycyrrhizic Acid and Silver Hydrogels for Accelerated Bacteria‐Infected Wound Healing
Fan Zhang, Chuanjin Yin, Xueju Qi, Chuanlong Guo, Xiaochen Wu
Abstract
Antibacterial hydrogels are intensively studied as wound dressings. Silk fibroin (SF) is chemical crosslinked to glycyrrhizic acid (GA) and silver to fabricate a hydrogel dressing with both antibacterial and anti-inflammatory properties. The SF/Ag/GA hydrogel exhibits high water content with acceptable mechanical properties, combines the good biocompatibility and biodegradability of SF, the antibacterial activity of silver, and the anti-inflammatory property of GA, capable to promote tissue regeneration during wound healing process, offering great potential as an alternative for wound dressings.
Topics & Concepts
FibroinBiocompatibilitySelf-healing hydrogelsWound healingChemistryWound dressingAntibacterial activityAntimicrobialSILKPolymer chemistryMaterials scienceBacteriaComposite materialOrganic chemistrySurgeryMedicineGeneticsBiologyWound Healing and TreatmentsSilk-based biomaterials and applicationsAntimicrobial Peptides and Activities