Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome
Dashuai Wang, Jia Wu, Sheng Le, Hongfei Wang, Jingjing Luo, Rui Li, Xing Chen, Yu Song, Lingfei Wu, Ping Ye, Xinling Du, Xiaofan Huang
Topics & Concepts
Proinflammatory cytokineCancer researchMatrix metalloproteinaseChemokineActivator (genetics)Thoracic aortaAortic aneurysmVascular smooth muscleMedicineInflammationCell biologyAortaInternal medicineBiologyReceptorSmooth muscleInflammasome and immune disordersAortic aneurysm repair treatmentsGenomics, phytochemicals, and oxidative stress