Litcius/Paper detail

Oltipraz, the activator of nuclear factor erythroid 2-related factor 2 (Nrf2), protects against the formation of BAPN-induced aneurysms and dissection of the thoracic aorta in mice by inhibiting activation of the ROS-mediated NLRP3 inflammasome

Dashuai Wang, Jia Wu, Sheng Le, Hongfei Wang, Jingjing Luo, Rui Li, Xing Chen, Yu Song, Lingfei Wu, Ping Ye, Xinling Du, Xiaofan Huang

2022European Journal of Pharmacology17 citationsDOI

Topics & Concepts

Proinflammatory cytokineCancer researchMatrix metalloproteinaseChemokineActivator (genetics)Thoracic aortaAortic aneurysmVascular smooth muscleMedicineInflammationCell biologyAortaInternal medicineBiologyReceptorSmooth muscleInflammasome and immune disordersAortic aneurysm repair treatmentsGenomics, phytochemicals, and oxidative stress