Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks
Alexandra S. Weinheimer, YiTing Paung, Julie Rageul, Arafat Khan, Natalie Lo, Brian Ho, Michael Tong, Sébastien Alphonse, Markus A. Seeliger, Hyungjin Kim
Abstract
as an essential element for SDE2 to exert its role in preserving replication fork integrity via fork protection complex regulation and highlight the structural diversity of the DNA-protein interactions achieved by a specialized DNA-binding motif.
Topics & Concepts
DNA replicationTer proteinBiologyReplication factor COrigin recognition complexEukaryotic DNA replicationReplisomeMinichromosome maintenanceControl of chromosome duplicationCell biologyReplication protein APre-replication complexDNA-binding domainDNA replication factor CDT1DNAGeneticsDNA-binding proteinTranscription factorGeneDNA Repair MechanismsGenomics and Chromatin DynamicsRNA Research and Splicing