New pyranopyrazole based derivatives: Design, synthesis, and biological evaluation as potential topoisomerase II inhibitors, apoptotic inducers, and antiproliferative agents
Eman A. Sobh, Asmaa E. Kassab, Eman A. El-Khouly, Marwa S. A. Hassan
Topics & Concepts
ChemistryDoxorubicinCytotoxicityA549 cellApoptosisTopoisomeraseCell cultureCytotoxic T cellCancer cellIn vitroPharmacologyBiochemistryCancer researchStereochemistryCancerChemotherapyBiologyGeneticsCancer therapeutics and mechanismsSynthesis and biological activitySynthesis and Biological Evaluation