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Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels

Hui Ma, Jinfeng Li, Xin Qiao, Yue Zhang, Xiaojuan Hou, Hai-Xia Chang, Honglei Chen, Yong Zhang, Yunfeng Li

2023Acta Pharmacologica Sinica23 citationsDOIOpen Access PDF

Topics & Concepts

Sigma-1 receptorKetamineAntidepressantPharmacologySigma receptorAgonistBehavioural despair testAntagonistChemistryGene knockdownNMDA receptorHippocampusReceptorMedicineInternal medicineNeurosciencePsychologyBiochemistryApoptosisPharmacological Receptor Mechanisms and EffectsTryptophan and brain disordersTreatment of Major Depression
Sigma-1 receptor activation mediates the sustained antidepressant effect of ketamine in mice via increasing BDNF levels | Litcius