Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer
Yuanke Li, Zhen Zhao, Chien‐Yu Lin, Yanli Liu, Kevin F. Staveley-O’Carroll, Guangfu Li, Kun Cheng
Abstract
This approach provides a new therapeutic avenue to improve the antitumor efficacy of PDAC therapies by normalizing tumor stroma using the PCBP2 siRNA nanocomplex.
Topics & Concepts
StromaGene silencingPancreatic cancerStromal cellCancer researchExtracellular matrixChemistryTumor microenvironmentCell biologyPathologyBiologyCancerMedicineInternal medicineBiochemistryGeneTumor cellsImmunohistochemistryPancreatic and Hepatic Oncology ResearchCancer Cells and MetastasisPhagocytosis and Immune Regulation