Visible‐Light‐Driven di‐<i>t</i>‐Butyl Peroxide‐Promoted the Oxidative Homo‐ and Cross‐Coupling of Phenols
Hanqiang Jia, Min He, Shilei Yang, Xiaoqiang Yu, Ming Bao
Abstract
Abstract The visible‐light‐induced oxidative homo‐ and cross‐coupling of phenols by di‐ t ‐butyl peroxide (DTBP) are described. These reactions occur with metal‐free process and feature high chemo‐ and regioselectivity under mild reaction conditions. DTBP is an inexpensive, benign, stable at room temperature, and commercially available oxidizer. It can be irradiated by blue LEDs to generate tert ‐butoxyl radical ( t BuO⋅), which induces the oxidative homo‐coupling of phenols and the cross‐coupling of phenols with naphthols, respectively.
Topics & Concepts
RegioselectivityChemistryPhenolsPeroxideOxidative coupling of methanePhotochemistryOxidative phosphorylationCoupling reactionVisible spectrumOrganic peroxideCoupling (piping)Organic chemistryCatalysisMaterials scienceBiochemistryOptoelectronicsPolymerCopolymerMetallurgyRadical Photochemical ReactionsAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization Methods