Review of Interface Modification Based on 2D Nanomaterials for Surface Plasmon Resonance Biosensors
Zhihui Mao, Xinsheng Peng, Yangyang Zhou, Yawen Liu, Kwangnak Koh, Hongxia Chen
Abstract
Surface plasmon resonance biosensors are drawing attention due to their real-time, label-free, and rapid characteristic. To detect trace biomarkers (ct-DNA, mi-RNA, PD-L1), plasmonic and metal oxide nanoparticles have been utilized for signal amplification and have shown exciting results. To achieve uniform, reproducible, simple, and sensitive sensor interface construction, two-dimensional materials such as graphene and molybdenum sulfide have opened a research upsurge and show a great possibility in the surface plasmon resonance biosensing field due to their unique large specific surface area, excellent in-plane electron transport effect, and singular optical properties. Here, we provide an overview of the recent research progress on two-dimensional materials in the field of surface plasmon resonance biosensors, including the optoelectronic properties of two-dimensional materials, sensitivity enhancement mechanism, and interface construction. Finally, the challenges and development directions of detection sensitivity enhancement are summarized and prospected. Our work will provide a useful platform to expand the further application of two-dimensional materials in surface plasmon resonance biosensors.