Cu-catalysed three-component C–H trifluoroalkylation of glycine derivatives: access to diverse CF<sub>3</sub>-containing amino acids
Yadong Li, Dengfu Lu, Yuefa Gong
Abstract
A Cu-catalysed and ligand-controlled glycine ligation method is developed for the modular and selective synthesis of diverse CF 3 -containing amino acids and dipeptides.
Topics & Concepts
ChemistryGlycineAmino acidLigand (biochemistry)Combinatorial chemistryComponent (thermodynamics)Modular designStereochemistryMedicinal chemistryBiochemistryReceptorComputer sciencePhysicsThermodynamicsOperating systemFluorine in Organic ChemistryInorganic Fluorides and Related Compounds