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Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways

Marianna Potenza, Martina Sciarretta, Maria Giovanna Chini, Anella Saviano, Francesco Μaione, Maria Valeria D’Auria, Simona De Marino, Assunta Giordano, R. Hofstetter, Carmen Festa, Oliver Werz, Giuseppe Bifulco

2021European Journal of Medicinal Chemistry27 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryEicosanoidIn vivoBiochemistryDrug discoveryArachidonate 5-lipoxygenaseBiosynthesisPharmacologyArachidonic acidEnzymeBiologyBiotechnologySynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects
Structure-based screening for the discovery of 1,2,4-oxadiazoles as promising hits for the development of new anti-inflammatory agents interfering with eicosanoid biosynthesis pathways | Litcius