CD44: a cancer stem cell marker and therapeutic target in leukemia treatment
Shuang Wu, Yicheng Tan, Fanfan Li, Yixiang Han, Shenghui Zhang, Xiaofei Lin
Abstract
CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.
Topics & Concepts
CD44Cancer stem cellHoming (biology)Stem cellCell adhesionExtracellular matrixLeukemiaCancer researchCell adhesion moleculeBiologyCell biologyCellImmunologyBiochemistryEcologyProteoglycans and glycosaminoglycans researchGlycosylation and Glycoproteins ResearchMultiple Myeloma Research and Treatments