New insights into ruthenium(<scp>ii</scp>) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviour
Dina Maciel, Nádia Nunes, Francisco Santos, Yu Fan, Gaoming Li, Mingwu Shen, Helena Tomás, Xiangyang Shi, João Rodrigues
Abstract
cell death mechanism studies showed the capacity of G2Ru to induce mitochondrial depolarization and ROS production. Altogether, pre-clinical results indicated G2Ru as a promising anticancer drug and the potential of low-generation poly(alkylidenamine)-based dendrimers as drug nanocarriers.
Topics & Concepts
NanocarriersRutheniumDrugAnticancer drugNanotechnologyCombinatorial chemistryMaterials sciencePharmacologyDrug deliveryChemistryMedicineOrganic chemistryCatalysisDendrimers and Hyperbranched PolymersMetal complexes synthesis and propertiesFerrocene Chemistry and Applications